Research has shown that with as few as 11 hours of mindful meditation, the white matter of the brain that aspartame destroys, can begin to grow back. Research into the brain damage that aspartame causes, has revealed lesions to the nerve fibers known as white matter. This is due to the by-products created when aspartame is ingested, namely methanol and formaldehyde. The effects of ingesting these chemicals are so serious that they cause symptoms often mistaken for multiple sclerosis. Other artificial sweeteners such as neotame, which have the same by-products, have the same effects.

An example is the destruction of the white matter in the anterior cingulate region which causes a lack of nerve activity in this area. This is associated with mental problems such as ADHD, ADD, dementia, depression and schizophrenia. Test subjects reported reduced feelings of anger, depression, anxiety and fatigue and had reduced levels of the stress hormone, cortisol. The changes include the improvement of mood, which in turn is consistent with self regulation being a core feature of many mental health problems.

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